The European Clinical Trials Regulation (EU CTR) took effect on 31 January 2022. Since then, authorities, sites and sponsors have had to embrace the new Regulation to begin to successfully run clinical trials across the EU. Since 31 January 2023, all clinical trial applications (CTAs) must be submitted through the Clinical Trials Information System (CTIS) and since then, all stakeholders have been dealing with its updates, challenges, revisions and simplifications. In this panel we were fortunate to be able to hear from the different perspectives: EMA, European Commission, industry and consultancy.