Welcome to the October 2026 issue of Regulatory Rapporteur which focuses on clinical trial design and real-world evidence.

When does a clinical trial really end? This October issue of Regulatory Rapporteur explores the evidence continuum from clinical trial design to real-world use, examining diversity, decentralised trials, AI-enabled pharmacovigilance, regulatory convergence, disclosure and the global implementation of Good Clinical Practice. Together, these contributions consider how data are generated, managed and interpreted across the product lifecycle and what this means for evidence-based decision-making.